Cica
Review the scientific evidence and bio-availability of Cica, followed by our curated database of formulations.
Cica (Centella asiatica), also known as Gotu Kola or Tiger Grass, is a perennial herbaceous plant native to the wetlands of Asia. Historically a staple in Ayurvedic and Traditional Chinese Medicine, it has gained modern nutritional prominence for its supportive regenerative properties. Legend suggests that wounded tigers would roll in the plant to soothe their injuries—hence the name “Tiger Grass”—a practice now validated by its high concentration of triterpene saponins which support dermal and neural recovery.
Clinical Benefits & Mechanism of Action
Cica functions primarily through its active compounds: asiaticoside, madecassoside, asiatic acid, and madecassic acid. These constituents interact with the body’s physiological repair mechanisms through several distinct pathways:
- Collagen Synthesis and Tissue Support: Cica supports the G-protein coupled receptor signaling that leads to the natural production of Type I and Type III collagen. It interacts with the expression of TGF-β (Transforming Growth Factor beta), a key cytokine involved in normal structural remodeling and extracellular matrix maintenance.
- Inflammatory Cascade Modulation: It helps maintain balanced levels of cytokines, specifically IL-1β, IL-6, and TNF-α, by modulating the NF-κB signaling pathway. This contributes to managing systemic oxidative stress and supporting skin comfort and vitality.
- Neural Resilience and Cognitive Support: From a neurobiological perspective, Cica functions as an adaptogen. It has been shown to support dendritic arborization and promote the normal upregulation of Brain-Derived Neurotrophic Factor (BDNF), supporting synaptic plasticity. Additionally, it interacts with GABAergic neurotransmission, promoting a state of neurological calm and relaxation without compromising alertness.
- Microcirculation Support: It helps maintain the structural integrity of blood vessels and capillaries, supporting normal venous function and peripheral circulation, which assists in the efficient delivery of nutrients to cellular tissues.
